The World's only Expert Curated Knowledgebase of Biomedical facts with unique Search & Analytics

XTractor Premium:

Semantic Knowledge discovery platform with Expert curated Knowledgebase for Biomedical Researchers.

Overview

XTractor Premium - a platform for discovery, analysis and modeling of published biomedical facts. The application also comes with - XTractor Premium Knowledgebase - the only knowledgebase which provides "manually" annotated facts from PubMed. XTractor - (basic version) has been widely adopted by the life sciences research community and has more than 2800 users from 350 organizations across the globe.

XTractor Premium enables you to,

Comprehensive coverage of information published every day in PubMed

Manually annotaed facts are added every single day from PubMed. To ensure that you donot miss out the any smallest facts in your day today research. From December 2009 onwards, XTractor covers the entire biomedical relevant set of PubMed abstracts published every single day. In addition to the most relevant facts we also provide you with all the abstracts with the mention of a single entity (be it a protein, drug, disease or biological process).
More than 100000 facts are added to the XTractor Premium knowledgebase every single month.

Reduce the amount of time required for data mining

Manually mined scientific data from PubMed delivered within 10 days from the date of publication.

Sentences categorised into 24 different categories for easy refining.

Precision based mining of relevant facts

Compared to Natural language processing engines- our manual annotation approach reduces false positives rate by 15-35%.

Analysis of the extracted facts

Highly Advanced Semantic, Bibliographic Search, Concept linking and extensive reports facilitate quicker analysis.

Stay Current with updates

Latest updates from PubMed delivered every week.

Watchlist feature to enable topic tracking.

Innovative Features

Semantic Search:

The first of its kind highly advanced search feature, where in one could query the XTractor Premium Knowledgebase using multiple ontologies. This would enable you to narrow down on your targets at ease.

Concept Linking:

Our advanced query feature would enable you to make assumptions from multiple abstracts, and discover facts, which are hitherto not published.

Bibliographic search:

Search based on author, organization or country.

Save, Export and Visualize:

Save and export the data in user-friendly formats, also XTractor Premium is made compatible with CytoScape - so one can visualize the networks also at ease.

Updates made through web services.

Web based and onsite installation available.

Drug Discovery

XTractor Highlights:

• 24 cateogries of XTractor for Drug Discovery researchers.
• 24 categories are defined in a way to help researchers in Target Discovery, Target Validation, Drug Studies, Toxicity, Clinical Trials.
• The Categories widely covers Pharmacokinetics, Drug toxicity Drug route of administration, Drug pharmacodynamics, knockout studies, mutation studies and biomarkers.

With our categorization find answers to Simple queries like:

• PK & PD studies of drug tamoxifen.
• cisplatin clinical trials.
• Knockout/RNAi studies, pertaining to Rheumatoid arthritis.
• Disease prognosis and diagnosis for Diabetes type 2.
• Drug- toxicity studies in Alzheimer? s patients.
• Pathways involving apoptosis and breast cancer.
• Marker/ Biomarker studies in colon cancer.
• Route of administration studies For insulin.
• Dose related and clearance Studies for doxorubicin.

With our categorization find answers to Complex queries like:

• Drugs for Rheumatoid Arthritis involving in GPCR class I receptors.
• Marker/ Biomarker in Breast Cancer patients For monitoring Toxicity induced by Tamoxifen.
• With combination of Manual annotation + Semantic Search capabilities obtain high precision outputs for your searches.
• Concept linking helps you to link Disease with common Drugs with common proteins and enables you to draw conclusions from multiple abstracts, and discover facts, which weren?t earlier, published.
• Get to know about the Top scientific searches.

How XTractor is helpful For Academic and Drug Discovery Researchers

Our Content:

• Manually annotated relationships for your favorite Proteins, Diseases, Drugs and Biological Processes.
• Manual Categorization of 24 different categories which includes Biomarkers, drug studies, pathway studies, knockout studies, mutation studies and many more.
• With XTractor, all synonyms for genes, proteins, processes or drugs are recognized, allowing all relevant information to be presented for each and every query.

Our Intelligence:

• Discover new relationships and frame hypothesis via concept linking.
• With combination of Manual annotation + Semantic Search capabilities obtain high precision outputs for your searches.

Our Search:

• Obtain highly accurate data everyday for your research with our advance search features.
• Query the system without typing keywords. By just clicking on - multiple - ontology terms with our semantic navigation feature.
• Track author, organization or country with our bibliographic search.
• Track competitors and organizations working on similar or related areas.
• Regular updates on your areas of interest with our watch list feature.
• Import the data onto your inhouse applications at ease.

Our Technology:

• Import the data on to your inhouse applications at ease.
• Sorting of the most relevant abstracts at ease.
• Customised downloadable Reports for your favorite biological and chemical entities.
• Network visualization via cytoscape enable you to dive deeper into the results and make useful assumptions.
• Helps you to export your personal data via XML or PDF Reports.
• Tag cloud feature helps you to track the most used keywords.
• Save your searches and retrieve back at anytime with our save and history feature.

Our Updates:

• Our regular updates of facts everyday keeps you updated with latest pubmed publications.
• Post december 2009 - XTractor not only provides an update of all the relevant biomedical facts from pubMed everyday but also those additional facts which may add value to your research.

Only Knowledgebase with daily* updations from PubMed

Perform searches over the entire XTractor Premium knowledgebase of more than relationships on proteins, drugs, biological process and diseases (which is ever growing).

XTractor Premium Knowledgebase Statistics:

The data content in XTractor Premium is highly diverse. Our scientists screen through the most relevant abstracts published by PUBMED everyday and on an average approx. 600 relationships/sentences get added to XTractor Premium everyday.

Hence in no time you get to access one of the largest and the most current manually annotated datasets.

* Updated daily & Delivered weekly

Flexibility to Integrate & Customize

XTractor Premium offers

• Flexibility to Customize
• Extend and Integrate in-house data
• Tools and federated data sources, as XTractor-Premium uses Standards like MeSH, UniProt GO and PubChem ontologies for mapping

Contact our sales team for customization requirements:

xtsales@molecularconnections.com

XTractor Product Comparison Chart

On an average more than 600 manually annotated facts from PUBMED get added to XTractor Premium everyday* free for the entire year.

* Updated daily & Delivered weekly

Search	XTractor BETA	XTractor PREMIUM
Archived Data Search to the XTractor    Knowledge Base	Limited
Advanced Summary search
Semantic search
Bibliographic Search
WatchList Search Features
The auto-complete search bar
Intelligence	XTractor BETA	XTractor PREMIUM
Semantic Search
Semantic Navigation
Concept Linking
Technology	XTractor BETA	XTractor PREMIUM
Fast filter Technology
Cytoscape based Visualization
Topic Tracking
Session Tracking
Save Searches
History recall
Results storage
Set up Alerts
Label Publications
XML Export
PDF Reports
Networking	XTractor BETA	XTractor PREMIUM
Group Sharing within XTractor Community
Group sharing within Organisation firewalls
Updates	XTractor BETA	XTractor PREMIUM
Regular updates of about 600 facts every day
Webservices for updations
Security	XTractor BETA	XTractor PREMIUM
Username Authentication
Session out time Security
Interface	XTractor BETA	XTractor PREMIUM
Web based Interface
Onsite Customization & integration
Flexibility	XTractor BETA	XTractor PREMIUM
In-house integration
Customisation services
Support Services	XTractor BETA	XTractor PREMIUM
Web Demonstration for Users
Onsite help
Online tutorials and user manual

Join us as we share some Re-purposing insights on some key cancer drugs through Semantic Knowledge discovery

Cancer can be biomedically interpreted as abnormal cell proliferation - A cascade of events characterized by changes in several biomedical entities like proteins, processes & drugs. Several Drugs influence cancer therapy and many of them may have applications in treatment of different cancer types or they may find uses in other disease areas as well. Drug repurposing has been gaining importance in the last few years as an increasing number of drug development and pharmaceutical companies see their drug pipelines drying up and realize that many previously promising NCEs have failed to deliver.

In this presentation we will demonstrate how XTractor Premium platform can be used to reveal the relationships of various drugs / genes / proteins targets and receptor types from manually annotated facts from published sources, semantically find links and facilitate forming hypotheses for potential Re-purposing & Therapeutic Switching. We will present a case study to showcase how evidences from literature can suggest or bring about a potential Drug Re-purposing.

We will also demonstrate  & help discover distinctive features influenced by common biomedical entities between several drugs, with the help of advanced semantic search and concept linking capabilities of our Semantic Knowledge discovery Platform with Expert curated Knowledgebase.  These searches can be applied to annotated facts within XTractor Platform or could be customized to work on any in-house, proprietary data sources of your organization.

Duration:45 minutes

RSVP:

For a personalized webex Please click here

Please contact Ashish [ ashish.b@molecularconnections.com ] for any queries.